Brenda Blethyn, convinced she'd be laughed out of town if she followed her dreams, remained a secretary for 10 years before plucking up the courage to enroll in acting school.
Sometimes a life is so shattered you just have to tread gently through the wreckage to find the human being at the centre of it.
Andrew Denton first met Annie Robinson during the 'Show and Tell' segment on Enough Rope two years ago. That's when he found out about the term 'metastatic cancer': cancer gone wild.
Ciaron O'Reilly is a devout Brisbane-born Christian pacifist.
He is one of the rarest species on Earth. A popular politician. He entered parliament in 1960 and was the Liberal with so much get up and go, that he ultimately got up and went.
Much like the brain surgery he does every day, Dr Charlie Teo is a challenging, highly complicated individual. The self described maverick, many patients see him as a miracle worker.
We all know a homeless person when we see one, right, they're that wino passed out in the doorway, or the person with their head down, sitting on the street corner begging for money.
One in four relationships in Australia will be scarred by domestic violence. It's a subject tinged with shame and too often kept out of sight.
In 1993, Andrew Denton proved that it's healthy, not sick, to poke fun at cancer.
The seeds of love can grow in the most unlikely soil. Shahin Shafaei and Gaby Schultz met in a detention centre. He was an asylum seeker from Iran, she was a guard from country New South Wales.
Matt Laffan was born with a debilitating condition and little expectation that he would survive.
Jimmy Webb is considered one of the world's greatest tunesmiths - 'Wichita Lineman', 'By The Time I Get To Phoenix', these are just some of his hits.
Life is full of journeys but rarely do any of us travel as far as Johnny Lee Clary.
He has been a hero to his people, an icon of their long and bloody struggle for independence.
Michael Parkinson has a reputation that is positively Bradmanesque, arguably the greatest the game has ever seen, he plays with style, grace and an unfailing sense of decency.
A world leader in the field of neuroscience, she's devoted her life to studying the 1.5kg of tissue that makes each one of us who we are.
When French novelist Emile Zola said 'I am here to live out loud', he could have been talking about Robert Hughes.
At just 26, Stephen Page became the artistic director of the internationally acclaimed Bangarra Dance Company.
Few of us could truly imagine what it's like to be without a limb, to go through life minus something everyone else has taken for granted.
The interview you're about to see is the equivalent of a guerilla raid on a heavily fortified position. The subject, Jeff Kennett, doesn't want to be interviewed.